JUUL and similar pod-based e-cigarettes have been popular with teenagers and young adults since they came on the market in 2015, but little has been known about their health effects.

A new systematic review led by researchers from Harvard T.H. Chan School of Public Health found that while the products may contain lower levels of harmful ingredients than conventional cigarettes, there is no evidence that even these lower levels are safe for youth. The study also found that the devices’ efficient delivery of nicotine fosters greater dependence than other types of e-cigarettes.

This is the first paper to synthesize research findings on pod-based e-cigarettes, said first author Stella Lee, formerly a National Cancer Institute Cancer Prevention postdoctoral fellow in the Department of Social and Behavioral Sciences and currently an assistant professor at Konkuk University in South Korea. The study will be published online June 1, 2020 in JAMA Pediatrics.

Pod-based e-cigarettes are sleekly designed and easy to conceal. Users pop in replaceable nicotine cartridges that come in appealing flavors like mango and mint. JUUL has dominated retail sales, although other pod-based products are now on the market, including Suorin, Bo, Phix, and Vuse Alto. Recent data have shown that e-cigarette use in adolescents has increased substantially since the introduction of pod-based e-cigarettes, prompting the U.S. Surgeon General to declare youth vaping an epidemic.

For this study, the researchers reviewed recent peer-reviewed scientific literature on pod-based e-cigarettes. They identified 35 English-language articles that presented primary data on pod-based e-cigarettes from June 2015 to June 2019. Studies looked at product design and biological effects, marketing and social media messaging, and population use and perception.

According to the new study, the design of pod-based e-cigarettes ensures the delivery of high doses of nicotine in a low pH form, which is less harsh compared to the higher pH nicotine found in most other e-cigarette brands, thus encouraging deeper inhalation. In one study, the level of nicotine exposure in adolescents (as measured by urinary cotinine) using JUUL or other brands of pod-based e-cigarettes was higher (245 ng/ml) than levels detected in adolescents who smoked regular cigarettes (155 ng/ml). Study findings also suggested that adolescents using pod-based e-cigarettes were more likely than other e-cigarette users to vape daily and to have more symptoms of nicotine dependence.

Read full article here.

Emily Henderson – News Medical Life Sciences – June 1, 2020.

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